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Scientific Resources HepaSH®
3D hepatic spheroids and liver‐organ on chip models displayed maintenance of hepatic functions and maturation profile in a long‐term culture of the humanized HepaSH cells
Authors: Hanyuan Wang, Carla Meschini, Stéphane Poulain, Soo Hyeon Kim, Hiroshi Arakawa, Yukio Kato, Cecile Legallais, Ulysse Pereira, Yasuyuki Sakai, Eric Leclerc
Journal: Biotechnol. Prog.
PMID: 40448434
Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/ STAT pathways
Authors: Hanyuan Wang , Stéphane Poulain , Wenxin Cao, Hiroshi Arakawa , Soo Hyeon Kim , Yukio Kato , Masaki Nishikawa, Yasuyuki Sakai , Eric Leclerc
Journal: Toxicology
PMID: 41285220
In Vitro Assessment of Drug-Induced Liver Injury Using Three-Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver
Authors: Liu X, Higuchi Y, Sakamoto Y, Yanagida S, Uehara S, Suemizu H, Kanda Y, Kawagishi H
Journal: J Appl Toxicol
PMID: 40686298
Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor
Authors: Mitamura R, Takemoto S, Aoyama Y, Morita K, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Fukami T, Nakano M, Nakajima M
Journal: Drug Metab Pharmacokinet
PMID: 40479899
3D hepatic spheroids and liver-organ on chip models displayed maintenance of hepatic functions and maturation profile in a long-term culture of the humanized HepaSH cells
Authors: Wang H, Meschini C, Poulain S, Kim SH, Arakawa H, Kato Y, Legallais C, Pereira U, Sakai Y, Leclerc E
Journal: Biotechnol Prog
PMID: 40448434
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Authors: Burban A, Tessier C, Larroquette M, Guyon J, Lubiato C, Pinglaut M, Toujas M, Galvis J, Dartigues B, Georget E, Luchman HA, Weiss S, Cappellen D, Nicot N, Klink B, Nikolski M, Brisson L, Mathivet T, Bikfalvi A, Daubon T, Sharanek A.
Journal: EMBO Mol Med
PMID: 39901019
Induction of drug metabolizing enzyme and drug transporter expression by antifungal triazole pesticides in human HepaSH hepatocytes
Authors: Zerdoug A, Le Vée M, Le Mentec H, Carteret J, Jouan E, Jamin A, Lopez B, Uehara S, Higuchi Y, Yoneda N, Chesné C, Suemizu H, Fardel O
Journal: Chemosphere
PMID: 39369742
Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation
Authors: Sakai Y, Fukami T, Tokumitsu S, Nakano M, Nakashima S, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Nakajima M
Journal: Drug Metab Pharmacokinet
PMID: 38797091
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells
Authors: Uehara S, Murayama N, Higuchi Y, Shimizu M, Suemizu H, Guengerich FP, Yamazaki H
Journal: Chem Res Toxicol
PMID: 38626399
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells
Authors: Uno Y, Uehara S, Ushirozako G, Murayama N, Suemizu H, Yamazaki H
Journal: Xenobiotica
PMID: 37800661