Wepredic
Scientific Resources HepaSH™
3D hepatic spheroids and liver‐organ on chip models displayed maintenance of hepatic functions and maturation profile in a long‐term culture of the humanized HepaSH cells
Hanyuan Wang, Carla Meschini, Stéphane Poulain, Soo Hyeon Kim, Hiroshi Arakawa, Yukio Kato, Cecile Legallais, Ulysse Pereira, Yasuyuki Sakai, Eric Leclerc; May 2025
Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/ STAT pathways
Hanyuan Wang , Stéphane Poulain , Wenxin Cao, Hiroshi Arakawa , Soo Hyeon Kim , Yukio Kato , Masaki Nishikawa, Yasuyuki Sakai , Eric Leclerc; November 2025
In Vitro Assessment of Drug-Induced Liver Injury Using Three-Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver
Liu X, Higuchi Y, Sakamoto Y, Yanagida S, Uehara S, Suemizu H, Kanda Y, Kawagishi H; July 2025
Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes
Mitamura R, Takemoto S, Aoyama Y, Morita K, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Fukami T, Nakano M, Nakajima M; March 2025
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Burban A, Tessier C, Larroquette M, Guyon J, Lubiato C, Pinglaut M, Toujas M, Galvis J, Dartigues B, Georget E, Luchman HA, Weiss S, Cappellen D, Nicot N, Klink B, Nikolski M, Brisson L, Mathivet T, Bikfalvi A, Daubon T, Sharanek A; February 2025
Induction of drug metabolizing enzyme and drug transporter expression by antifungal triazole pesticides in human HepaSH hepatocytes
Zerdoug A, Le Vée M, Le Mentec H, Carteret J, Jouan E, Jamin A, Lopez B, Uehara S, Higuchi Y, Yoneda N, Chesné C, Suemizu H, Fardel O; February 2025
Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation
Sakai Y, Fukami T, Tokumitsu S, Nakano M, Nakashima S, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Nakajima M; March 2024
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells
Uehara S, Murayama N, Higuchi Y, Shimizu M, Suemizu H, Guengerich FP, Yamazaki H; March 2024
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki; November 2023