Scientific Resources HepaRG®

  • HepaRG® Characterization & Culture Modes


    • Expression of Cytochromes P450, Conjugating Enzymes and Nuclear Receptors in Human Hepatoma HepaRG Cells

    Aninat C., Corlu A., Glaise D. et al., 2006

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    • ​The Human Hepatoma HepaRG Cells: A Highly Differentiated Model for Studies of Liver Metabolism and Toxicity of Xenobiotics

    Guillouzo A., Corlu A., Aninat C. et al., 2007

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    • ​Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

    Jossé R., Aninat C., Glaise D. et al., 2008
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  • CYP Induction

    • HepaRG Cells as an In Vitro Model for Evaluation of Cytochrome P450 Induction in Humans

    Kanebratt K.P., Andersson T.B., 2008
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    • ​Functional Expression, Inhibition and Induction of CYP Enzymes in HepaRG Cells

    Turpeinen M., Tolonen A., Chesné C. et al., 2009

    • ​Evaluation of Multiple In Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery

    McGinnity D.F. et al., 2009

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  • Clearance

    • Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs

    Zanelli U., Caradonna N.P., Hallifax D., Houston J.B., 2012

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    • ​Evaluation of HepaRG Cells as an In Vitro Model for Human Drug Metabolism Studies

    Kanebratt K.P., Andersson T.B., 2008

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    • ​Cytochrome P450-Dependent Metabolism in HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor

    Darnell M. et al., 2011

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  • Hepatotoxicity

    • HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity

    McGill M.R., Yan H.M., Ramachandran A. et al., 2010

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    • Comparative Proteomic Characterization of Four Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation and Detoxication

    Sison-Young R.L.C., Mitsa D., Jenkins R.E. et al., 2015
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    • ​Functional Comparison of HepaRG Cells and Primary Human Hepatocytes in Sandwich and Spheroid Culture as Repeated-Exposure Models for Hepatotoxicity

    Li J., Settivari R.S., LeBaron M.J., Marty M.S., 2019
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  • Steatosis

    • Induction of Vesicular Steatosis by Amiodarone and Tetracycline Is Associated with Up-Regulation of Lipogenic Genes in HepaRG Cells

    ​Antherieu S., Rogue A., Fromenty B. et al., 2011
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    • ​Advantageous Use of HepaRG Cells for the Screening and Mechanistic Study of Drug-Induced Steatosis

    Tolosa L., Gómez-Lechón M.J., Donato M.T. et al., 2016
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    • ​PPAR Agonists Reduce Steatosis in Oleic Acid-Overloaded HepaRG Cells

    Rogue A., Spire C., Brun M. et al., 2014
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  • Cholestasis

    • Functional Expression of Sinusoidal and Canalicular Hepatic Drug Transporters in Differentiated HepaRG Cells

    Le Vée M., Jigorel E., Glaise D. et al., 2006
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    • Impact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG Cells

    Bachour-El Azzi P., Sharanek A., Burban A. et al., 2014
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  • Reactive Metabolites

    • Formation of GSH-Trapped Reactive Metabolites in Human Liver Microsomes, S9 Fractions, HepaRG Cells and Human Hepatocytes

    Lassila T., Rousu T., Tolonen A. et al., 2015
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    • ​Optimization of the HepaRG cell model for drug metabolism and toxicity studies

    Antherieu S., Chesné C. et al., 2013
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    • ​Hepatic Bioactivation of Skin-Sensitizing Drugs to Reactive Metabolites

    Chong Huai L., Ng C. et al., 2019
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  • Genotoxicity

    • Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

    Jossé R., Aninat C., Glaise D. et al., 2008
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    • ​Application of HepaRG Cells in Genotoxicity Testing: A Review

    Guo X., Fowler P., El Yamani N. et al., 2024
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  • Virology

    • Infection of a Human Hepatoma Cell Line by Hepatitis B Virus

    Gripon P., Rumin S., Urban S. et al., 2002
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    • ​Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

    Lucifora J., Xia Y., Reisinger F. et al., 2014
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    • ​Sodium Taurocholate Cotransporting Polypeptide Is a Functional Receptor for Human Hepatitis B and D Virus

    Yan H., Zhong G., Xu G. et al., 2012
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  • Fibrosis

    • In Vitro Modeling of Liver Fibrosis with 3D Co-Culture System Using a Novel Human Hepatic Stellate Cell Line

    Kim J., Kim J., Lee Y.B. et al., 2023
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    • In Vitro Modeling of Liver Fibrosis in 3D Microtissues Using Scalable Micropatterning System

    Zahmatkesh E., Mehrvarz S. et al., 2022
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    • Amplified Response of Drug-Induced Liver Fibrosis via Immune Cell Co-Culture in a 3D In Vitro Hepatic Fibrosis Model

    Jung H., Kyun M., Kwon J.I. et al., 2024
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  • Endocrine Disruption

    • Assessment of Endocrine Disruptor Impacts on Lipid Metabolism in a Fatty Acid-Supplemented HepaRG Human Hepatic Cell Line

    Bernal K., Touma C. et al., 2024
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    • ​Assessment of Endocrine Disruptor Impacts on Lipid Metabolism in a Fatty Acid-Supplemented HepaRG Human Hepatic Cell Line

    Langou S., Blanc E.B., Coumoul X. et al., 2024
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