HepaRG®


A human hepatic cell model, unique in its ability to fully differentiate into mature and functional hepatocytes

  • FIT FOR ALL PURPOSES
    HepaRG® cells are metabolically competent, express the main hepato-biliary transporters and develop bile canaliculi under 2D and 3D configurations.

  • EXTENDED FUNCTIONALITIES
    HepaRG® cells conserve full expression of hepatic functions up to 4 weeks, making them suitable for long-term exposure.

  • SUSTAINABLE SOURCE OF HUMAN HEPATOCYTES
    Sustainability ensured by a well-established HepaRG® bank providing cells at affordable prices.

Contact Us

Applications

  1. In vitro Toxicology

    Bile Canaliculi Dysfunction, Steatotic liver disease (SLD),  Fibrosis,  Genotoxicity, Mitotoxicity, Endocrine disruption, Reactive metabolite formation, Infectious liver diseases, Testing of gene therapy products

  2. Drug discovery

    Infectious liver disease, Hepatic fibrosis, SLD (MASLD, MetALD, ...), Insulin signaling pathways

  3. DMPK

    Clearances:   Phase I, Phase II and Phase 3 clearance, metabolite formation. Drug-Drug Interaction including CYP phenotyping and CYP induction.

  4. Liver models

    2D, 3D, MPS, Cocultures

Our HepaRG® products

Contact Us

Our products and services

Experimental studies

HepaRG® Scientific Publications

Discover peer-reviewed publications highlighting the use of HepaRG® as a gold-standard human hepatic model for investigating drug metabolism and pharmacokinetics (DMPK), toxicity, and the biological mechanisms involved in liver physiology and disease.


View Publications
Contact Us