HepaRG™

A human hepatic cell model, unique in its ability to fully differentiate into mature and functional hepatocytes

FIT FOR ALL PURPOSES
HepaRG® cells are metabolically competent, express the main hepato-biliary transporters and develop bile canaliculi under 2D and 3D configurations.
EXTENDED FUNCTIONALITIES
HepaRG® cells conserve full expression of hepatic functions up to 4 weeks, making them suitable for long-term exposure.
SUSTAINABLE SOURCE OF HUMAN HEPATOCYTES
Sustainability ensured by a well-established HepaRG® bank providing cells at affordable prices.

In vitro Toxicology

Bile Canaliculi Dysfunction, Steatotic liver disease (SLD), Fibrosis, Genotoxicity, Mitotoxicity, Endocrine disruption, Reactive metabolite formation, Infectious liver diseases, Testing of gene therapy products
Drug discovery

Infectious liver disease, Hepatic fibrosis, SLD (MASLD, MetALD, ...), Insulin signaling pathways
DMPK

Clearances: Phase I, Phase II and Phase 3 clearance, metabolite formation. Drug-Drug Interaction including CYP phenotyping and CYP induction.
Liver models

2D, 3D, MPS, Cocultures